Glucose-6-Phosphate
 Isomerase and Fructose-l;6-Bisphosphate Aldolase Activities in Regenerating Rat Liver after Partial Hepatectomy

Keimyung Medical Journal 1996;15(2):111-118.

Glucose-6-Phosphate Isomerase and Fructose-l;6-Bisphosphate Aldolase Activities in Regenerating Rat Liver after Partial Hepatectomy

흰쥐 재생간에서의 Glucose-6-Phosphate Isomerase 및 Fructose-1;6-Bisphosphate Aldolase의 활성도

김일경; 곽춘식; 문교철

Abstract

This study was made in order to understand the changes involved with glucose-6-phsophate isomerase(GPI) and fructose-1; 6-bisphosphate aldolase(ALS) activities in regenerating rat liver Cytosolic; mitochondrial and microsomal GPI and ALS activities were determined in regenerating liver tissue following 70%(median and left lateral lobes) partial hepatectomy in rats for a period of ten days The activities of these enzymes in serum were also measured. The activities of cytosolic and microsomal GPI in regenerating rat liver tissue showed a significant increase from the twelfth hour to the sixth day; and the from twelfth hour to the first day; respectively; following the partial hepatectomy. However; the mitochondrial GPI activity did not change The activities of both cytosolic and mitochondrial ALS m regenerating rat liver tissue showed a significant increase from the first day to the second day following the partial hepatectomy. However; microsomal ALS in regenerating liver tissue increased significantly from the twelfth hour to the second day following the partial hepatectomy. The activities of both GPI and ALS m rat serum showed a significant increase from the twelfth hour to the third day following the partial hepatectomy. In view of the above results; the presence of both GPI and ALS in regenerating rat liver suggest the enzymes increase their biosynthesis tn the regenerating stage

Key Words: Fructose-l, 6-bisphosphate aldolase, Glucose-6-phosphate isomerase, Regenerating rat liver