| Thiol
Methyltransferase Activity in Regenerating
Liver after Partial Hepatectomy in Rats |
| 흰쥐 재생간에서의 Thiol Methyltransferase 활성도 |
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주일; 문교철; 곽춘식 |
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| Abstract |
Changes of thiol
methyltransferase (TMT) activity; and it's Km and
Vmax values in cytosolic; mitochondrial and microsomal fractions in regenerating
rat livers were determined over a period of ten days after 70% partial (median
and left lateral lobes) hepatectomy. The enzyme activity in serum was also
measured. Mitochondrial and microsomal TMT activities after partial hepatectomy
were found to be significantly increased between the first and the second day; and
between the twelfth hour and the third day of regeneration; respectively; whereas
the cytosolic TMT activity increased at the second day after partial hepatectomy.
On the other hand; the serum TMT activity did not change. The Vmax values of
the cytosolic; mitochondrial and microsomal TMTs were significantly increased at
the second day after partial hepatectomy. However; the Km values of the above
hepatic enzymes did not vary in all the experimental groups. Therefore; the above
results
indicate that the biosynthesis of TMT was increased during regeneration of
rat liver. |
| Key Words:
Partial hepatectomy,
Regenerating rat liver, Thiol methyltransferase |
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