Glucagon-Stimulated 
and Postprandial Plasma C-peptide Values as a Guide for Insulin Treatment in Patients with Diabetes

Keimyung Medical Journal 1990;9(4):455-460.

Glucagon-Stimulated and Postprandial Plasma C-peptide Values as a Guide for Insulin Treatment in Patients with Diabetes

당뇨병환자에 있어서 치료방법 선정에 식후 2시간 혈청 C-peptide치와 Glucagon자극후 혈청 C-peptide치의 의의

서영숙; 손수인; 이인규; 안성훈; 이형우; 이현우

Abstract

Basal; postprandial (2hour after breakfast); and glucagon stimulated serum C-peptide concentrations were determined in 22 patients with diabetes who admitted in Keimyung Univeristy Dongsan Medical Center and Youngnam University Hospital. Basal and postprandial C-peptide values were measured on two consecutive days to estimate the degree of variation of C-peptide secretion. The results were as follows: 1. Mean fasting and postprandial C-peptide concentrations in 15 insulin requiring diabetic patients were 0.7+0.2ng/ml; l.l+0.3ng/ml on first day. 0.9± 0.4ng/ml; l.l+0.4ng/ml on second day and in non insulin requiring diabetic patients were 1.5+ 0.5ng/ml; 2.5± 0.7ng/ml on first day. 1.5+ 0.5ng/ml; 2.8+ 0.7ng/ml on second day. The mean C-peptide values of 15 insuln requiring diabetic patients were significantly lower than those of 7 non insulin requiring diabetic patients(p<0.05; P<0.001). 2. There were no differences in fasting and postprandial C-peptide values between two consecutive day. 3. The postprandial C-peptide values on two consecutive days were postiviely correlated with the serum C-peptide values after a glucagon administration(r= 0.86; 0.75). Above results suggested that postprandial and glucagon stimulated C-peptide values are very sensitive guides for a insulin treatment in patients with diabetes.

Key Words: C-peptide, Diabetes, Glucagon