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Keimyung Medical Journal 2016;35(1):44-49.
Published online June 22, 2016.
Autoimmune Hepatitis-systemic Lupus Erythematosus Overlap Syndrome Diagnosed after Tapering Immunosuppressive Therapy.
Bho Hyeon Lee, Seung Ah Park, Joo Kyung Kim, Dae Young Cheon, Seong Hun Kang, Nan Young Choi, Ji Won Park, Mi Jung Kwon, Young Il Seo, Sung Eun Kim
1Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
2Department of Pathology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
3Department of Gastroenterology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea. sekim@hallym.or.kr
4Division of Rheumatology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
Abstract
The differential diagnosis of systemic lupus erythematosus (SLE) and autoimmune hepatitis (AIH) is difficult due to the resemblance of these two disorders. However, the accurate diagnosis is important for prognosis and treatment that are different from each other. We report a case of AIH-SLE overlap syndrome which tapering of prednisone and azathioprine therapy deteriorated the condition of a patient due to flare up of SLE. The patient was a 28-year-old woman diagnosed as AIH. After administrations of prednisone and azathioprine, her condition was improved. During dose reduction, she was admitted to our hospital as fever and dyspnea. She diagnosed as lupus nephritis. After high dose treatment with corticosteroids and azathioprine, she recovered. Once the diagnosis of autoimmune disease such as SLE or AIH has been made, clinicians should also be fully aware of concomitant other autoimmune disease.
Key Words: Autoimmune hepatitis, Overlap syndrome, Systemic lupus erythematosus
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