| Dopaminergic Influence on the Increase of Hasma Aldosterone level by Metoclopramide in Mice
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| Metoclopramide에 의한 혈장 Aldosterone치 증가작용에 대한 Dopamine성 영향 |
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김수경 |
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| Abstract |
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The biosynthesis and secretion of aldosterone in adrenal gland is well known to be regulated by several factors. Especially; angiotensin II; ACTH; extracellular potssium are dominent factors. Recent studies suggest that dopamine may be a physiological regulator of aldosterone secretion. Therefore; the present study was undertaken to examine whether change of aldosterone response on metoclopramide is mediated by dopaminergic receptor. The results obtained were summarized as follows;
1. The plasma aldosterone level was significantly increased by metoclopramide( lOmg/kg) and ACTH(5u7kg); but not affected by dopamine (5mg/kg).
2. The metoclopramide-induced increase of plasma aldosterone level was significantly augmented by ACTH; but inhibited by dopamine. The ACTH-induced increase of plasma aldosterone level was slightly inhibited by dopamine.
3. The plasma sodium concentration was slightly increased by metoclopramide and ACTH; but not affected by dopamine.
4. The metoclopramide or ACTH-induced increase of plasma sodium concentration was inhibited by dopamine. The metoclopramide-induced increase of plasma sodium concentration was not affected by ACTH.
5. The plasma potassium concentration was slightly decreased by metoclopramide and ACTH; but significantly increased by dopamine.
6. The metoclopramide-induced decrease of plasma potassium concentration was not affected by ACTH; but significantly inhibited by dopamine. The ACTH-induced decrease of plasma potassium concentration was slightly inhibited by dopamine.
The above results suggest that the increase of aldosterone secretion by metoclopramide is presumably mediated by dopaminergic receptor. |
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