Activities of Alcohol Metabolizing Enzymes in Regenerating1 Rat Liver

Keimyung Medical Journal 1988;7(2):280-287.

흰쥐 재생간의 알콜대사효소들의 활성치

김여희; 문교철; 곽춘식; 정성광

Abstract

A study was made on the changes in the activities of the following during 10 post-operative days: alcohol dehydrogenase; microsomal ethanol-oxidizing system; catalase;cysosolic; microsomal and mitochondrial aldehyde dehydrogenase of regenerating rat livers after 70% (median and left lateral lobes) partial hepatectomy. After partial hepatectomy in the rats; activities of regenerating liver alcohol dehydrogenase significantly increased in the sixth day. The activities of microsomal ethanol-oxidizing system in the regenerating liver markedly increased from the third day after partial hepatectomy. However; no significant changes in hepatic catalase was noted throughout the experiments. The activities of cytosolic and microsomal aldehyde dehydrogenase in the regenerating liver significantly increased from the sixth day and the third to the sixth day respectively; but mitochondrial aldehyde dehydrogenase showed no change.