| Effect of Chlorambucil on the Reproductive Cells of Male Mice |
| Chlorambucil이 수컷 생쥐의 생식세포에 미치는 영향 |
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김덕훈; 김곤섭; 이인환; 장성익; 최인장 |
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| Abstract |
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The present study was performed to investigate the effects of chlorambucil on the reproductive cells of male mice.
The animal was treated with daily injection of chlorambucil(16mg/kg) for periods up to 35 ■days.
The morphological; changes in reproductive cells of male mice were observed with light microscope after routine preparation.
The results are summarized as follows:
1. Testis; epididymis; prostate; and body weight were increased in control groups; however; in the experimental groups; these were severely decreased.
2. The diameter of seminiferous tubule and the height of germinal epithelium cell were ?decreased; and more numbers of spermatogonia A; spermatogonia B; spermatocyte; spermatid; and spermatozoa were severely decreased. After 35 days treated with chlorambucil; almost all ?spermatozoa were lost in seminiferous tubules.
3. During the process of treatment; the frequency of cell debris; vacuolations; piknotic nuclei; -and multinucleated giant cells were markedly appeared in the germinal epithelial cells.
4. The severe hyperplasia of Leydig cell was revealed; however; the Sertoli cell was not ■affected with treatment.
These results indicate that the chlorambucil causes ultimate lesions for the production of reproductive cell in all stages of the spermatogenesis.-
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