Malignant Fibrous Histiocytoma

Keimyung Medical Journal 1983;2(2):199-207.

악성 섬유 조직구종

권건영; 장은숙; 정재홍

Abstract

Malignant Fibrous Histiocytoma (MFH) has become a well known malignant tumor of soft tissue since its description by O'Brien and Stout, and Stout and Lattes proposed as having a common origin from the tissue histiocyte, but there are different opinion that MFH is a neoplasm of undifferentiated mesenchymal cell with binary differentiation into histiocyt?id and fibroblastic cells. ) Irrespective of its precise histogenesis, the tumor contains both fibroblast-like and histiocyte-like cells in varying proportions, accounting in part for its broad morphologic spectrum. The major microscopic characteristics include fibrogenic areas with spindle cells(fibroblast-like) arranged in a focal storiform pattern, clusters or sheets of histiocyte-like cells, benign and malignant giant cells, foam cells, inflammatory cells, scattered mitotic figures are frequently observed. This report presents a case of malignant fibrous histiocytoma arising in the previous laparotomy scar of low abdominal wall, where had been previously irradiated, of 39-year-old female patient who had had history of total abdominal hysterectomy with left salpingo-oophorectomy for cervical carcinoma on February 24, 1977’ radiation therapy after hysterectomy, right salpingo-?ophorectomy for infiltrating papillary carcinoma of right ovary on April 18，1978, and after that Co therapy for 27 days, total 5400 rad, till June 15, 1978，and right hemicolectomy with ile?-colostomy for postoperative intestinal obstruction on November 11, 1978. It is our aim in this report to discuss histogenesis and to emphasize on the development of prognostic criteria of MFH.