| Morphological
Changes on Lymphoid Tissue of the Adult Rabbit Through the Injection of Prednisolone
|
| Prednisolone 투여로 인한 가토중추임파조직의 형태학적연구 |
|
하재창; 홍석재; 이동구 |
|
|
|
|
| Abstract |
|
This study was carried out
to investigate morphological changes in the central lymphoid tissue of thymus gland and appendix of 12 healthy adult rabbits treated with injecting prednisolone of 5 and 10mg each to the animals once per day for 3 consecutive days. The results were as follows:
Light microscopically; a considerable loss of lymphocytes in lobular cortex of thymus gland; along with noticeable increase of macrophages and reticulum cells; were found. However; no significant decrease of lymphocytes in its medulla persent. Significant loss of large and small lymphocytes and considerably increased macrophages in the areas of dome; corona; and follicles of appendiceal lymphoid tissue were noted. However; very meagre decrease of lymphocytes in thymus dependent area only was noticed.
Electron microscopically marked degeneration and necrotic changes of lymphocytes; such as irregularity of nulear margin; loss of nuclear membrane; and destruction of lymphocytes in the cortex of thymus gland occured. in reticulum cells and macrophages; cystic degeneration of vesicles; swelling of mitochondria; loss of cristae; and phagocytosis of destructed lymphocytes were prominent in the group of lOmg injection than in that of 5mg. Nevertheless; nuclear condensations and irregularities of nuclear margin of some lymphocytes were noticed in medulla with no clear degenerative changes. In appendiceal lymphoid tissue; a severe nocrotic changes of lymphocytes of dome; corona and follicles were observed. However; its changes in thymus dependent area were very little. In macrophages of dome and follicles; destructed lymphocytes were seen to be occasionally phagocytosed.
It may be summarized that: the effects of corticosteroid on the central 'lymphoid tissue take place in lymphocytes in cortex of thymus gland and in lymphocytes of B Irmphocytical area of appendiceal lymphoid tissue. It may also be assumed that the changes aforementioned can include irreversible necrosis.
|
| Key Words:
Prednisolone, 가토중추임파조직, 흉선, 충수임파조직 |
|
PDF Links
Full text via DOI
Download Citation
