Pseudolipoma of Glisson’s capsule is a rare benign condition, with an incidence of 0.2%, occurring in the subcapsular space of the liver. It is characterized by encapsulated degenerative fat. This lesion is believed to develop when the epiploic appendage detaches and adheres to the liver capsule. In this report, we present the case of a 69-year-old female patient who developed a hepatic pseudolipoma that was observed to migrate during routine chest computed tomography (CT) follow-up scans for a pulmonary nodule. To date, there has only been one other reported case of a migrating hepatic pseudolipoma. This report discusses her case in detail and provides a review of the relevant literature.

A 69-year-old female patient came for evaluation of an incidentally discovered pulmonary nodule. Her initial physical examination and vital signs were unremarkable. The patient had no significant medical history aside from a right knee replacement due to osteoarthritis, and she reported no history of abdominal surgery or trauma.

A non-contrast chest CT scan conducted upon admission showed no notable abdominal findings. However, pulmonary findings included multiple nodules, calcifications, and bronchiectasis, along with enlarged and calcified mediastinal lymph nodes.

Six months later, a follow-up chest CT revealed a new 1.4 cm nodule with fat density (–89 HU) in the liver’s posterolateral aspect (Fig. 1A, 1B). The patient remained asymptomatic concerning any abdominal complaints.

Fourteen months after the initial evaluation, another chest CT scan showed that the previously identified nodule, suspected to be a hepatic pseudolipoma, had migrated to the posteromedial aspect of the liver without significantly changing size (Fig. 1C, 1D).

Pseudolipoma of the liver was first described by Rolleston in 1891 as a mass of degenerative fat surrounded by the liver capsule [1,2]. CT imaging usually shows a well-defined nodule with fat attenuation on the liver surface [3-5]. It mainly affects middle-aged male, with some studies suggesting a possible link to trauma or previous surgeries [6]. This case report discusses a hepatic pseudolipoma that developed and migrated during the follow-up period. Pseudolipomas are typically found on the diaphragmatic surface of the liver and have a histological appearance similar to that of epiploic appendages. In this instance, the lesion was initially located on the posterolateral aspect of the liver and later migrated to the posteromedial aspect. This observed migration supports the hypothesis that a lipomatous mass originating from an epiploic appendage can move between the serosa of the liver and Glisson’s capsule, ultimately forming a pseudolipoma [7].

Differentiating hepatic pseudolipoma from other conditions, such as serosal metastasis or fibrosing subcapsular necrotic nodules, is crucial due to their overlapping imaging features [4]. The mobility observed in this case is a distinct feature that may help differentiate pseudolipomas from other conditions in challenging situations. However, due to the rarity of such occurrences, further studies and additional case reports are needed to understand better the clinical significance and implications of the movement of pseudolipomas. This case highlights that hepatic pseudolipomas can migrate over time, potentially improving our understanding of their pathogenesis and assisting in future differential diagnoses.