A Case of Floral Variant of Follicular Lymphoma |
A Case of Floral Variant of Follicular Lymphoma |
Jung Min Lee; Kang Kook Lee; Sun Kyung Park; Jin Young Kim; Young Rok Do; Keon Uk Park; Hong Suk Song; Ki Young Kown |
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Abstract |
Floral variant of follicular lymphoma is uncommon and it shows floral appearance caused by
atypical lymphocytes that irregularly invade and invaginate into the germinal center. [I1]A 59
year-old man presented with incidentally found peribronchial lymph node by chest X-ray. It had
been hard to biopsy so the patient received lobectomy of the left lower lung. Microscopic findings
were similar to lymphoepithelioma-like carcinoma or metastatic carcinoma in lymph nodes. The
tumor showed irregularly shaped germinal center-like lesion; which look like progressive
transformation of germinal center. Immunohistochemical stains showed positive for CD20; bcl-6;
CD 10 and negative for CD3; CD5 and bcl-2. We treated this patient with CHOP chemotherapy
regimen. Initial CT scan revealed an enlarged lymph node at the medial basal segment of the left
lower lobe of the lung. Follow[W사2] up chest CT scan after treatment revealed complete
resolution of the tumor mass. Floral variant of follicular lymphoma was first described in 1987 by
Osborne and Butler. [I3]The histologic features are similar to those of progressive transformation
of germinal center (PTGC) and nodular lymphocyte predominant Hodgkin lymphoma (NLPHL).
Clinical presentation and subsequent clinical course of the floral variant of follicular lymphoma are
not different to usual cases of follicular lymphoma.[I4] Our case was diagnosed as a floral variant
of follicular lymphoma by histologic feature. It was treated by excisional biopsy and
chemotherapy. |
Key Words:
CHOP, Follicular lymphoma, Marginal zone B-cell lymphoma, Nodal marginal
zone lymphoma |