| Antimicrobial Drug Susceptibility of Escherichia coli Isolated from Clinical Specimens |
| 임상가검물에서 분리된 대장균의 항균제 감수성 |
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서성일; 백원기; 서민호 |
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| Abstract |
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One hundred and forty-six Escherichia coli isolated from various clinical specimens in Daegu area
were tested for antimicrobial drug susceptibility to 32 drugs including cefepime; meropenem;
levofloxacin and moxifloxacin. Escherichia coli were most frequently isolated from urine (59.6%);
and followed by blood (18.5%); sputum (11.6%) and etc. All strains were susceptible to
imipenem; meropenem and doxycycline. Only 1.4-9.6% of the strains were resistant to
cefoperazone; cefotaxime; cefepime; aztreonam; amikacin; and rifampin. The resistance
frequencies of amoxicillin/clavulanate; cephalothin; cefaclor; cefamandole; cefoxitin; streptomycin;
kanamycin; gentamicin; netilmicin; tobramycin; norfloxacin; ofloxacin; levofloxacin; moxifloxacin;
chloramphenicol and tetracycline were 15.1-33.6%. The resistance frequencies of ampicillin;
nalidixic acid; ciprofloxacin; sulfisoxazole; trimethoprim and cotrimoxazole were 39.7-61.6%. All
strains were resistant to erythromycin. MIC90 of cefoperazone; cefotaxime; aztreonam; imipenem;
amikacin; doxycycline and rifampin were 4-16 μg/mL; and those of ampicillin;
amoxicillin/clavulanate; cefamandole; cefoxitin; netilmicin; tobramycin; norfloxacin; and
ciprofloxacin were 32-128 μg/mL. MIC90 of cephalothin; cefaclor; streptomycin; kanamycin;
gentamicin; nalidixic acid; tetracycline; sulfisoxazole; trimethoprim and cotrimoxazole were 256 to
more than 2048 μg/mL. Isolation frequencies of multidrug resistant strains were very high. Forty
four (35.7%) strains were multiply resistant to 11-26 drugs and 22 (17.9%) strains were multiply resistant to 6-10 drugs. |
| Key Words:
Antimicrobial susceptibility, Cefepime, Escherichia coli, Imipenem, Levofloxacin,
Meropenem, Moxifloxacin |
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