| The Comparison of Efficacy Between Concurrent Chemoradiotherapy
and Hepatic Arterial Infusion Therapy in Hepatocellular Carcinoma |
| 간세포암에서 간동맥 항암-방사선요법과 간동맥 항암 단독요법의 비교 |
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김태열; 황재석; 조광범; 박경식; 정우진; 장병국; 김은수; 이경인; 이선영; 최재혁; 최종환 |
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| Abstract |
Background/Aims
: Patients with advanced hepatocellular carcinoma showed a poor prognosis
and there is no curative therapy. The aim of this study was to compare the therapeutic efficacy of
concurrent chemoradiotherapy (CCRT) and hepatic arterial infusion therapy (HAIT) in advanced
HCC. Methods : Between April 2004 and April 2009; thirty four patients (CCRT; 15 and HAIT;
19) with advanced HCC (BCLC stage C) were included in this study. The patients received 5-FU
(250 mg)/ Cisplatin 10 mg)/leucovorin (12 mg) for 5 days every 3 weeks via implanted
chemoport. In CCRT group; patients were treated with external beam radiotherapy (4500 cGy/5
weeks) in addition to HAIT. After 2 cycles of all these therapies; abdominal CT and serum α-FP
were checked to evaluate therapeutic efficacies. Results : In patients treated with CCRT or HAIT;
response rates after 2 cycles were 73.3% (PR 11; SD 2; PD 2) vs 10.5% (PR 2; SD 9; PD 8);
respectively (p=0.001). The median survival time of CCRT group was 142 days compared with
166 days for HAIT (p=0.577). Conclusions : CCRT can achieves more favorable results in
advanced HCC with good reserve liver function compared with HAIT but there was no differences
in median survival times between two groups; Thus further investigation is required to assess long term response rate and overall survival. |
| Key Words:
Carcinoma, Concurrent chemoradiotherapy, Hepatic arterial infusion therapy,
Hepatocellular |
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