Silibinin induces apoptosis in HL-60 and K562 leukemia cells |
백혈병 세포주에서 Silibinin의 세포자멸사 유도 효과 |
정희정; 백원기 |
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Abstract |
Silibinin is a polyphenolic flavonoid antioxidant isolated from the milk thistle and is
used clinically to treat certain liver diseases. Recently it has been reported that silibinin has
anticancer properties. However; the cellular and molecular mechanisms underlying silibinin
induced growth inhibition in cancer cells are not clearly understood. In this study; we have
investigated whether silibinin exerts anti-proliferative and apoptotic effects on HL-60 and K562
human leukemia cells. It was found that silibinin inhibits cell proliferation in a dose-dependent
manner inducing apoptotic cell death. These findings suggest that silibinin could be a candidate for
anti-leukemic drug. |
Key Words:
Apoptosis, HL-60, K562, Leukemia, Silibinin. |
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