| Gene Expression in the Renal Damage Induced by Cisplatin |
| Cisplatin에 의해 유도된 신장 손상시의 유전자 발현 |
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백철민; 곽춘식; 하은영; 김여희; 최혜정; 황은아; 박성배; 김현철; 문교철 |
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| Abstract |
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Cisplatin; an antitumor agent widely used in the treatment of a variety of human
solid tumors; has nephrotoxicity. To understand the mechanism for the nephrotoxicity; the gene
expression patterns of renal tissues were measured. Sprague-Dawley rats received a single
intraperitoneal injection of 8 mg/kg of cisplatin and sacrificed 6 days after cisplatin injection. The
genes showed significant changes in expression are 111 genes; are associated with a broad range
of functional activities; including apoptosis; cell cycle; cell growth/maintenance; immunoresponse;
response to stress; signal transduction; transcription; and metabolism. The expression of the fifty
two genes was increased; and that of fifty nine genes was decreased. Especially; the expression
of the genes associated with apoptosis such as Spp1; Tubb5; Hmox1 and Clu was increased. And
the expression of the genes associated with cell cycle such as Pttg1; Ccng1 and Anxa1 was also
increasd. These results suggest that cisplatin induce nephrotoxicity by the changes of gene
expression involved in apoptosis and cell cycle. |
| Key Words:
Cisplatin, Gene expression, Renal Damage |
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