| Comparison between Oral and Vaginal Administration of Misoprostol for Induction of Labor |
| 분만 유도를 위한 경구용과 경질용 Misoprostol의 비교 |
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배진곤; 신소진; 박준철; 권상훈; 조치흠; 이정호; 차순도; 윤성도; 김종인 |
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| Abstract |
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Recently; some studies reported that transvaginal misoprostol induced successful
vaginal delivery.
The aim of this study were to compare the efficacy and the safety between oral and vaginal
administration of misoprostol for the induction of labor. Pregnant women who were hospitalized
for the induction of labor from January 2004 to December 2006 at the Dong san Medical Center
were included for the prospective randomized study. Subjects as a change in Bishop score of ≥3;
Bishop score of ≥6 at 12 hours; or vaginal delivery after the insert placement. One hundred
seventy-one women (Oral misoprostol group 85 women / Vaginal misoprostol group 86 women)
completed the protocol. There were no statistically significant differences between the two
groups in terms of a successful outcome (61.2% vs 67.4%; p=0.223) and the following mean time
to vaginal delivery (13.3 hours vs 14.5 hours ; p=0.722). In addition; no differences were
observed in the incidences of cesarean delivery; hyperstimulation syndrome; abnormal fetal heart
tate patterns; and adverse neonatal outcomes. We concluded that both misoprostol administration
routes were equally effective in achieving cervical ripening initiating labor; and achieving a
successful vaginal delivery. |
| Key Words:
Induction of labor, Misoprostol, Oral or vaginal administration |
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