Complications and Risk Factors of Mortality in Organophosphate Intoxication

Keimyung Medical Journal 2007;26(1):49-58.

유기인산제 음독의 합병증과 사망률에 여향을 미치는 위험요소 분석

이응갑; 정덕원; 황희영; 김혜인; 문성수; 전희정; 박관식; 이종명; 장현아; 김능수

Abstract

The most common cause of acute drug intoxication in Korea is organophosphate intoxication. Organophosphate suppresses cholinesterase activity; leading to unique clinical features by stimulating of muscarinic and nicotinic receptors and central nerve system symptoms. In the present study; major complications and risk factors of mortality were analyzed to predict clinical outcomes of patients in organophosphate intoxication. Among 84 patients who visited Kyungbook University Hospital's emergency medical center due to organophosphate from Jan. 2000 to May 2006; the medical records of 70 patients were analyzed retrospectively. Fourteen patients were excluded because they were transferred to other hospitals or discharged against medical advice during treatment. Among the various variables; mortality rate was significantly increased in cases of patients over 70 years old (p<0.05); hypotension (p<0.05) and bradycardia (p<0.05) at presentation and acute renal failure (p<0.001) during treatment. In logistic regression analysis; old age over 70 years (p<0.05) and acute renal failure (p<0.01) showed statistical significance. Old age and acute renal failure were poor prognostic factors in acute organophosphate intoxication.

Key Words: Complication, Mortality rate, Organophosphate intoxication, Risk factors