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Keimyung Medical Journal 2005;24(2):156-165.
Effects of Intravenous Administration of Taurocholic Acid on Lysosomal -D-Glucosidase and -D-Glucuronidase Activities of Serum and Liver in Rats with Choledocho-Caval Shunt
총담관 대정맥문합수술을 한 쥐에서 혈청과 간의 라이소즘 α-D-Glucosidase 및 β-D-Glucuronidase 활성도에 미치는 Taurocholic Acid의 정맥내 투여의 효과
김여희; 최혜정; 곽춘식
Abstract
The effects of intravenous administration of high concentration of taurocholic acid (TCA) on α-D-glucosidase nad β-D-glucuronidase activities in rat liver lysosomes were studied. Above liver lysosomal enzymes; serum lysosmal α-D-Glucosidase and total β-D-Glucosidase activities were determined from the experimental rats with choledocho-caval shunt (CCS). The activities of liver lysosomal α-D-Glucosidase and β-D-Glucosidase as well as the activities of serum lysosomal α-D-Glucosidase and total β-D-Glucosidase were significantly increased in the CCS plus TCA injection group than in control group; such as group of CCS alone group. However; these hepatic and serum enzymes activities did not change in the CCS plus tauroursodeoxycholic acid injection group. The above results suggest that TCA stimulates the biosynthesis of the lysosomal α-D-Glucosidase and β-D-Glucosidase in the liver. And that the elevated lysosomal α-D-Glucosidase and total β-D-Glucosidase activities in the serum are most likely due to increased hepatocyte membrane permeability caused by TCA mediated liver cell necrosis.
Key Words: Choledocho-caval shunt, α-D-Glucosidase, β-D-Glucuronidase, Taurocholicacid


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