Characteristics of 
MAGE as Cancer Diagnosis Marker

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Keimyung Medical Journal 2003;22(Suppl):125-130.

Characteristics of MAGE as Cancer Diagnosis Marker

암 진단지표로서 MAGE의 특성

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Abstract

The human MAGE A family encodes products that can be recognized by autologous cytotoxic T cells. Because MAGE genes are silent in most normal tissues except testis but are activated in a variety of neoplastic lesions; MAGE antigens represent ideal targets for cancer diagnosis and immunotherapy. MAGA A family consists of 12 subtypes; and there are high DNA homology between subtypes. Here; I discussed the importance of MAGE as cancer diagnosis marker and molecular methods for the detection of several MAGE subtypes together by RT-PCR using common primers.

Key Words: Cancer diagnosis marker, Melanoma antigen gene

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