| Cardiovascular
Autonomic Dysfunction in Patients with Liver Cirrhosis |
| 간경변증 환자에서 심혈관계 자율신경 기능이상 |
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김혜순; 김미정; 조광범; 황재석; 안성훈; 박승국 |
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| Abstract |
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Autonomic neuropathy has
been reported in association with liver
cirrhosis. Cardiovascular autonomic nerve function was tested in fourteen healthy
control subjects and twenty-six liver cirrhosis patients. Heart rate response to
Valsalva maneuver and to deep breathing; and immediate heart rate response to
standing were used to assess parasympathetic function. Blood pressure response
to standing and to sustained hand grip were used to assess sympathetic function.
Cardiovascular autonomic dysfunction was diagnosed when at least one response
of five tests was abnormal. The cirrhosis patients were also subdivided into two
groups according to the indocyanine green (ICG) secretion test abnormality (cut
off value 15%); and into three groups according to the Child-Pugh classification
respectively. One (7%) of fourteen control subjects and fifteen (58%) of twenty-six
cirrhosis patients showed evidence of cardiovascular autonomic dysfunction. One
(17%) of six patients with normal ICG test; and fourteen (70%) of twenty
patients with abnormal ICG test showed abnormal test results. Five (38%) of
thirteen patients with Child-Pugh classification A; and ten (77%) of thirteen
patinets with Child-Pugh classification B and C showed cardiovascular autonomic
dysfunction. These results show that cardiovascular autonomic dysfunction is
common in the liver cirrhosis patients; and parallels with disease severity. |
| Key Words:
Autonomic dysfunction,
Indocyanine green test, Liver cirrhosis |
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