| Effect of Intravenous
Administration of Taurocholate on
Hepatic Glyoxalase II Activity in Cholestatic Rats |
| 담즙울체 쥐에서 Glyoxalase Ⅱ 활성도에 미치는 Taurocholate의 정맥 내 투여의 효과 |
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곽춘식; 정상호; 김여희 |
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| Abstract |
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The possible mechanisms of
decreased glyoxalase Ⅱ (GLO-Ⅱ)
activity in cholestatic rat liver was studied. Hepatic GLO-Ⅱ activity was
determined from the experimental rats with choledocho-caval shunt (CCS) or bile
duct obstruction (BDO). The Michaelis-Menten constant in this hepatic enzyme
was also measured. The activity of hepatic GLO-Ⅱ as well as the Vmax value was
found to be decreased significantly in both CCS plus taurocholic acid (TCA)
injection group; and BDO plus TCA injection group than in each control group
such as CCS alone and BDO alone. However; the GLO-Ⅱ activity did not change
in both the CCS plus tauroursodeoxycholic acid injection group and the BDO plus
tauroursodeoxycholic acid injection group. On the other hand; the Km value of the
GLO-Ⅱ did not vary in any experimental groups. Above results suggest that TCA
repress the biosynthesis of GLO-II in the liver. |
| Key Words:
Bile duct obstruction,
Choledocho-caval shunt, Glyoxalase Ⅱ,
Taurocholic acid, Tauroursodeoxycholic acid |
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