| Effect of Intravenous
Administration of Taurocholate on Hepatic
Phenylacetyltransferase Activity in Common Bile Duct Ligated Rats |
| 총담관을 결찰한 쥐에서 간의 Phenylacetyltransferase 활성도에 미치는 Taurocholate의 정맥내 투여의 영향 |
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김일경; 김여희; 곽춘식 |
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| Abstract |
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The effect of intravenous
administeration of high dose taurocholate
on phenylacetyltransferase (PAT) activity was studied in rat liver. PAT activity;
and it’s Km and Vmax values were determined in the liver cytosolic;
mitochondrial and microsomal fractions isolated from the common bile duct (CBD)
ligated rats; which were injected with taurocholic acid (TCA); The activities of
liver cytosolic; mitochondrial and microsomal PAT as well as their Vmax values
were found to be significantly increased in the CBD ligation plus TCA injected
group than in the control group; such as CBD ligation alone group. However; their
Km values in the experimental group did not vary. On the other hand; these hepatic
enzyme activities did not change in the CBD ligation plus tauroursodeoxycholic
acid injected group. Therefore; the above results indicate that TCA stimulates
biosynthesis of the PAT in the liver |
| Key Words:
Common bile duct ligation,
Phenylacetyltransferase, Taurocholic acid |
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