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Keimyung Medical Journal 2002;21(1):91-99.
Effect of Intravenous Administration of Taurocholate on Liver Lysosomal α-D-Glucosidase and β-D-Glucuronidase Activities in Rats with Extrahepatic Cholestasis
담즙울체 쥐에서 간 라이소옴의 α-D-Glucosidase와 β-D-Glucosidase 활성도에 미치는 Taurocholate의 정맥내 투여의 영향
박소경; 김여희; 곽춘식
Abstract
The effects of intravenously administered of high concentration of taurocholic acid (TCA) on α-D-glucosidase and β-D-glucuronidase activities in rat liver lysosomes were studied. These liver lysosomal enzymes; and serum lysosomal α-D-glucosidase and total β-D-glucuronidase activities were also determined in experimental rats with common bile duct ligation (CBDL). The activities of liver lysosomal α-D-glucosidase and β-D-glucuronidase as well as the activities of serum α-D-glucosidase and total β-D-glucuronidase were found to be significantly increased in the CBDL plus TCA injected group than in the control group such as CBDL alone group. On the other hand; these serum and hepatic enzymes activities did not change in the CBDL plus tauroursodeoxycholic acid injected group. The above results suggest that TCA induces biosynthesis of the lysosomal α-D-glucosidase and β-D-glucuronidase in the liver and that the elevated lysosomal α-D -glucosidase and total β-D-glucuronidase activities in the serum are most likely due to increased hepatocyte membrane permeability caused by TCA mediated liver cell necrosis.
Key Words: Common bile duct ligation, α-D-Glucosidase, β-D-Glucuronidase, Taurocholic acid.


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