Effect of Intravenous
Administration of Taurocholate on Liver
Lysosomal α-D-Glucosidase and β-D-Glucuronidase
Activities in Rats with Extrahepatic Cholestasis |
담즙울체 쥐에서 간 라이소옴의 α-D-Glucosidase와 β-D-Glucosidase 활성도에 미치는 Taurocholate의 정맥내 투여의 영향 |
박소경; 김여희; 곽춘식 |
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Abstract |
The effects of intravenously
administered of high concentration of
taurocholic acid (TCA) on α-D-glucosidase and β-D-glucuronidase activities in rat
liver lysosomes were studied. These liver lysosomal enzymes; and serum lysosomal
α-D-glucosidase and total β-D-glucuronidase activities were also determined in
experimental rats with common bile duct ligation (CBDL). The activities of liver
lysosomal α-D-glucosidase and β-D-glucuronidase as well as the activities of serum
α-D-glucosidase and total β-D-glucuronidase were found to be significantly
increased in the CBDL plus TCA injected group than in the control group such as
CBDL alone group. On the other hand; these serum and hepatic enzymes activities
did not change in the CBDL plus tauroursodeoxycholic acid injected group.
The above results suggest that TCA induces biosynthesis of the lysosomal α-D-glucosidase
and β-D-glucuronidase in the liver and that the elevated lysosomal α-D
-glucosidase and total β-D-glucuronidase activities in the serum are most likely
due to increased hepatocyte membrane permeability caused by TCA mediated liver
cell necrosis. |
Key Words:
Common bile duct ligation,
α-D-Glucosidase, β-D-Glucuronidase,
Taurocholic acid. |