Analysis of 
Eradication Rate of Helicobacter Pylori by
Treatment Regimen of Triple Therapy and Dual Therapy
Using 14C-Urea Breath Test

Keimyung Medical Journal 2002;21(1):76-82.

Analysis of Eradication Rate of Helicobacter Pylori by Treatment Regimen of Triple Therapy and Dual Therapy Using 14C-Urea Breath Test

14C-요소 호기검사를 이용한 Helicobacter pylori의 3제요법과 2제요법의 제균율 분석

이승현; 전상훈; 서창균; 김상현; 이영석; 허재웅; 전석길; 안성훈

Abstract

Helicobacter pylori (H. pylori) infection is associated with chronic active gastritis; duodenal and gastric ulcers; gastric adenocarcinoma; and gastric lymphoma. The eradication of H. pylori not only results in the healing of ulcer but also reduces recurrence of peptic ulcer. Using 14C-urea breath test; we compared the efficacy of omeprazole-based triple therapy and dual therapy in patients with H. pylori-positive peptic ulcer. Seventy nine H. pylori-positive patients with peptic ulcer were enrolled and randomly divided into two groups. Fifty nine patients received triple therapy (omeprazole; clarithromycin and amoxicillin) for 7 days and twenty patients received dual therapy (omeprazole and clarithromycin) for 14 days. The eradication of H. pylori was assessed by 14C-urea breath test 4-8 weeks after the completion of each therapy. The overall eradication rate of H. pylori; using 14C-urea breath test; was 88.1% in the triple therapy group and 35% in the dual therapy group; therefore the eradication rate of triple therapy was higher than that of dual therapy.

Key Words: Helicobacter pylori, 15C-urea breath test, Gastric ulcer, Duodenal ulcer