A Case of 
Dimethylformamide-induced Toxic Hepatitis

Keimyung Medical Journal 2001;20(2):211-216.

A Case of Dimethylformamide-induced Toxic Hepatitis

디메틸포름아미드(dimethylformamide)에 의한 독성 간염 1례

정인성; 이충원

Abstract

Dimethylformamide is a solvent used extensively in the chemical industry. The effect of it’s exposure in human are not well documented. However; liver is the main organ afflicted after acute or chronic exposure. We report a patient with toxic hepatitis induced by dimethylformamide. His job was textile coating. He complained fatigue; alcohol intolerance; facial flushing and nausea. He had abnormally high serum aminotransferase level. The amount of urinary excretion of N-methylformamide was 300 ㎍/㎖. Possibilities of viral hepatitis; autoimmune hepatitis and alcoholic hepatitis were ruled out by his personal history and serological study. Liver function became normal after management for a month.

Key Words: Dimethylformamide, Toxic hepatitis