Effects of 
intravenous Administration of Taurocholate on Liver Lysosomal Cathepsin B and D; and Acid Phosphatase Activities in Rats with Extrahepatic Cholestasis

Keimyung Medical Journal 2001;20(2):145-153.

Effects of intravenous Administration of Taurocholate on Liver Lysosomal Cathepsin B and D; and Acid Phosphatase Activities in Rats with Extrahepatic Cholestasis

담즙울체 쥐에서 간 라이소솜의 Cathepsin B 및 D와 Acid phosphatase 활성도에 미치는 Taurocholate의 정맥 내 투여의 영향

박소경; 김여희; 곽춘식

Abstract

The effects of intravenous administration of high concentration of taurocholate on cathepsin B and D; and acid phosphatase activities in rat liver lysosome were studied. These liver lysosomal enzymes were determined in experimental rats with common bile duct ligation (CBDL). The activities of liver lysosomal cathepsin B and D; and acid phosphatase were found to be significantly increased in the CBDL plus taurocholic acid (TCA) injection group than in control group; such as CBDL alone group. However; these hepatic enzyme activities did not change in the CBDL plus tauroursodeoxycholic acid injection group. The above results suggest that TCA induces biosynthesis of the lysosomal cathepsin B; D and acid phosphatase in the liver.

Key Words: Acid phosphatase, Cathepsin B, Cathepsin D, Common bile duct ligation, Taurocholic acid