Keimyung Med J Search

CLOSE


Keimyung Medical Journal 2001;20(1):78-83.
Effect of Mefenamic Acid (PontalR) for Early Closure of Symptomatic Patent Ductus Arteriosus in Full-term Infants
유증상 동맥관 개존을 가진 만삭아에서 Mefenamic Acid(Pontal_R)의 조기 폐쇄 효과
차규동; 조윤정; 김천수; 김명성; 이상락; 김준식; 권태찬
Abstract
The Patent ductus arteriosus (PDA) is an essential structure that occurs normally in the fetus and becomes abnormal only when it persists after birth. Indomethacin; ibuprofen and mefenamic acid; prostaglandin synthetase inhibitors; have been shown to close the ductus arteriosus in a large portion of premature infant. To investigate the effect of mefenamic acid(Pontal) for the early closure of symptomatic PDA(s-PDA) in full-term infants; we analyzed twenty-nine cases who were admitted to NICU of Dong San Medical Center; Keimyung University during the period from July 1995 to June 1999. The diagnosis of s-PDA was made by clinical(Modified Yeh's criteria) and echocardiographic findings. Among 29 cases; 15 cases were treated with lasix plus mefenamic acid(Pontal group); and the other 14 cases were treated with lasix alone(control group). The rate of PDA closure and clinical courses of both groups were compared. Mean gestational age; birth weight; sex; and clinical findings have similar distribution in both groups. The closure rate within 2 weeks was significantly higher in the Pontal group(73.3%) than that of the control group(14.3%)(p<0.005); and no significant complications were identified in both groups. Mefenamic acid can be used as an effective drug for the early closure of symptomatic PDA in full-term infants with no significant side effects.
Key Words: Symptomatic patent ductus arteriosus, Mefenamic acid(Pontal), Full-term infants
TOOLS
Share :
Facebook Twitter Linked In Line it
METRICS Graph View
  • 715 View
  • 0 Download
Related articles in Keimyung Med J


ABOUT
BROWSE ARTICLES
EDITORIAL POLICY
FOR CONTRIBUTORS
Editorial Office
1095 Dalgubeol-daero, Dalseo-gu, Daegu 42601, Korea
Tel: +82-53-258-7581    E-mail: tinlib@dsmc.or.kr                

Copyright © 2025 by Keimyung University School of Medicine.

Developed in M2PI

Close layer
prev next