| Classification of Amyloidosis by Immunohistochemical Method and Potassium Permanganate Reaction: Correlation Between Morphology, Chemical Types and Clinical Features |
| Classification of Amyloidosis by Immunohistochemical Method and Potassium Permanganate Reaction: Correlation Between Morphology, Chemical Types and Clinical Features |
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박관규; 박성배; 김현철 |
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| Abstract |
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Systemic amyloidosis is a rare
disorder; which usually occurs in aged people with a poor prognosis. Forty-five patients with amyloidosis were studied by light microscopy with Congo red staining; potassium permanganate reaction and immunohistochemistry. The biopsy sites were abdominal fat; rectum; lung; bone marrow; liver; pleura; duodenum; gallbladder; colon; oral cavity; larynx; thyroid and skin. The patients were classified according to immunohistochemistry and Congo red staining results after potassium permanganate treatment. Thus; 21 of 45 (46.7%) cases were classified as AA (amyloid A protein); and 24 (53.3%) cases were classified as AL (amyloid light chain) amyloidosis. This study suggests that the association of these two techniques; potassium permanganate reaction and immunohistochemical stain; is more reliable than clinical data alone in distinguishing between AA and AL amyloidosis.
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| Key Words:
AL amyloidosis,
AA amyloidosis, Potassium permanganate, Immunohistochemistry |
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