Levels of Malondialdehyde and Antioxidant Enzymes in Plasma from Patients with End Stage Renal Disease

Keimyung Medical Journal 1999;18(2):177-183.

여미영; 문교철

Abstract

The patients with end stage renal disease show several complications due to oxygen free radicals. There might be some alterations in damages related oxygen free radicals and antioxidant systems in patients with end stage renal disease. Malondialdehyde and three well-known antioxidant enzyme levels in plasma were measured before and after hemodialysis. Before dialysis; malondialdehyde level in the plasma from the patients with end stage renal disease was higher than those from healthy controls. Superoxide dismutase and glutathione peroxidase activities in patients were lower than those from healthy controls. Plasma catalase activity was similar with normal control value. After hemodialysis; malondialdehyde level was still higher. Superoxide dismutase and glutathione peroxidase activities were returned to normal level and catalase activity was increased after hemodialysis. Our results suggest that there is an overproduction of superoxide anion with an impairment in disposition of hydrogen peroxide in patients with end stage renal disease. These alterations may contribute the patients with end stage renal disease susceptible to oxidant damages. Although single hemodiaysis is not helpful for protection of the damage induced by oxygen free radicals; it is helpful for normalizing the activities of antioxidant enzymes; especially superoxide dismutase and glutathione peroxidase.

Key Words: Catalase, End stage renal disease, peroxide dismutase