Balanced Anesthesia
 with Nalbuphine Hydrochloride (Nubain®)

Keimyung Medical Journal 1998;17(2):247-254.

Balanced Anesthesia with Nalbuphine Hydrochloride (Nubain®)

Nalbuphine HCL(Nubain)을 이용한 균형마취

배정인

Abstract

Nalbuphine hydrochloride produces agonistic analgesic effects at the kappa-recepter and antagonistic effects at the mu-recepter. The aim of this study was to evaluate the hemodynamic effects of nalbuphine hydrochloride during balanced anesthesia. 20 patients; American Society of Anesthesiologists physical status I and II; were scheduled for elective surgery. All patients were administered nalbuphine hydrochloride and glycopyrrolate IM 60 min. for premedication. Induction was established with pento-thal sodium and succinylcholine after preoxygenation. 1.0 mg/kg of nalbuphine hydrochloride was administered more than 1 min. period in bolus. N2O/O2 (2:1); nalbuphine hydrochloride; and non-depolarizing muscle relaxant were administered for maintenance. The mean age of the patients was 49 ±6.8 years and there were eight men and twelve women. The duration of the operation and recovery time were 207 ±3.3 min. and 247 ± 34.8 min. respectively. The mean arterial pressure was 93.6 ±7.8 mmHg preoperatively; 116.2±18.0 mmHg intraoperatively; 95.1±14.8 mmHg postoperatively. The arterial blood gases were analysed for the evaluation of ventilatory function. The PaC02 was 42.9 ±2.8 mmHg preoperatively; 41.1±1.2 mmHg postoperatively. The Pa02 was 91.9±6.42 mmHg preoperatively; 93.8±3.91 mmHg postoperatively. pH was 7.39±0.03 preoperatively; 7. 35 ±0.02 postoperatively. There were no statistically significant differences regarding vital signs; arterial blood gas analysis and respiratory rate measured at preoperative; intraoperative; and postoperative states. Taken these all together; we conclude that nalbuphine hydrochloride is the safe drug for balanced anesthesia because of its cardiovascular stability; no respiratory disturbance; tolerable postoperative pain; rapid recovery of consciousness; few side effects; drug toxicity and low cost of drug.

Key Words: Balanced anesthesia, Nalbuphine.