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Keimyung Medical Journal 1996;15(3):237-243.
Changes of Serum Interleukin-6 Level after Prednisolone Treatment in Patients with Subacute Thyroiditis
아급성 갑상선염 환자에서 Prednisolone 투여 후 혈청 Interleukin-6치의 변화에 관한 연구
박근용; 이인규; 조광범; 김경환; 박진용; 이동욱; 김인환; 임태형; 한승엽
Abstract
Recent studies have shown that increased serum IL-6 concentrations in patients with thyroid cell damage induced by inflammatory and noninflammatory processes are associated with leakage of IL-6 from thyrocytes. To investigate the changes in serum IL-6 concentrations; we evaluated serum levels of T4; thyroglobulin and ESR in subacute thyroiditis during treatment with corticosteroid. Six female patients were evaluated within 10 days after the onset of fever; palpitation and pain in the thyroid. Serum samples were obtained to measure serum T4; TSH; Tg; TSH-receptor antibody(TRAb); IL-6 by RIA and ESR. These parameters except for TRAb were measured before predinisolone treatment; 7 days; 14 days; 42 days after prednisolone treatment. The dose of prednisolone administered was started at 30mg/day; and tapered gradullay at intervals of 7 days. 1) The serum T4 concentration was increased above normal in the untreated condition (13.63±1.38|jg/dl) and decreased progressively with time after prenisolone(PDN) treatment (12.68+1.07ng/dl; 11.04±0.90jug/dl(P <0.05); 9.87± 1.17|jg/dl(P<0.05). 2) The serum thyroglobulin(Tg) concentration was increased above normal in the untreated condition (170. 67±107.99ng/dl) and decreased progressively with time after PDN treatment (86.83±23.19ng/ml(P<0.05); 55. 48±21.08ng/ml(P<0.05); 11.79±7.83ng/ml(P<0.05)). 3) Levels of ESR was increased above normal in the untreated condition(41.83±7.31mm/hr) and decreased rapidly after PDN treatment (23.00±6.07mm/hr(P<0.05); 17.00±4.90mm/hr (PC0.05); 16.50±12.24mm/hr(P<0. 05)).
Key Words: subacute thyroiditis, interleukin-6, prednisolone
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