Changes of 
Immediate Early Gene Induction in the Drug-Induced Seizure Models

Keimyung Medical Journal 1996;15(3):224-230.

Changes of Immediate Early Gene Induction in the Drug-Induced Seizure Models

간질 발작시에 나타나는 조기유전자 발현의 변화

박창교; 김수경

Abstract

Cellular immediate early gene expressions have been demonstrated to be modulated in response to a variety of seizure-inducing stimuli. In this study; two immediate early genes; c-fos and c-myc were investigated in response to the convulsants such as kainic acid(KA; lOmg/kg; ip); pentylenetetrazole(PTZ; 40mg/kg; ip); and N-methyl-D-aspartate(NMDA; 60mg/kg; ip) in three regions of rat brain : cerebral cortex; striatum; and brain stem. The KA and PTZ treatment slightly increased the transcription of c-fos in cerebral cortex; striatum; and brain stem. The MK-801 or baclofen pretreatment did not block the elevated expression of c-fos by KA and PTZ treatment. The NMDA treatment showed a reversal response of KA and PTZ treatment. The c-myc expres?sion did not show a significant change in each of convulsant treatment groups and MK-801 or baclofen pretreatment did not exhibit considerable differences. Therefore; c-fos could be one of the first seizure-related genes expressed in a cascade of events underlying different post-translational products; which result in diverse functional consequences depending on the brain sites

Key Words: c-fos, c-myc, convulsants