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Keimyung Medical Journal 2014;33(2):152-158.
Published online December 31, 2014.
Effect of Isotretionin for Refractory Solid-pseudopapillary Tumor of the Pancreas which Previously did not Respond to Anticancer Drugs and Radiation Therapy.
Yoon Jung Kim, Young Joon Ahn, Hee Jung Lee, Hye Ra Jung, Ok Bae Kim, Kyoung Sook Won, Ji Yoon Kim, Heung Sik Kim
1Department of Pediatrics, Keimyung University School of Medicine, Daegu, Korea. kimhs@dsmc.or.kr
2Department of Radiology, Keimyung University School of Medicine, Daegu, Korea.
3Department of Pathology, Keimyung University School of Medicine, Daegu, Korea.
4Department of Radiation Oncology, Keimyung University School of Medicine, Daegu, Korea.
5Department of Nuclear Medicine, Keimyung University School of Medicine, Daegu, Korea.
Abstract
Solid pseudopapillary neoplasm (SPN) of the pancreas is an exocrine tumor with low malignant nature. Although it's treatment of choice is complete surgical resection, the patients who are not eligible for surgical therapy need other kinds of therapy and there are little reports. Vitamin A and its derivatives in some tumors are known to be prohibiting the tumors' growth by reducing the manifestation of transcription factors. We present one case of SPN of the pancreas, which was not eligible for resection and was not responding to chemotherapy and radiation therapy, but, responded with the administration of Isotretionin (Roaccutan(R)). Therefore, for inoperable SPN of the pancreas, we consider Isotretionin therapy can be used as treatment and, in the future, new studies with more of Isotretionin treatment implemented cases should be conducted to identify their anticancer mechanism.
Key Words: Isotretionin, Solid-pseudopapillary neoplasm of the pancreas, Treatment
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