Serum Mitochondrial Aspartate Aminotransferase Activity in Common Bile Duct Ligated Rats

Keimyung Medical Journal 1987;6(2):271-276.

총담관을 결찰한 흰쥐 혈청의 Mitochondrial Aspartate Aminotransferase의 활성치

김여희; 문교철; 곽춘식

Abstract

To study the effect of hepatobiliary disorders on serum mitochondrial aspartate aminotransferase activity; total and mitochondrial aspartate aminotransferase were determined in serum after the ligation of common bile duct in rats. The activity of hepatic mitochondrial aspartate aminotransferase was also measured. The activity of total aspartate aminotransferase in serum drastically elevated between the twelve hours and forty-two days after the ligation of common bile duct in rats. However; the mitochondrial aspartate aminotransferase activity in serum showed a marked increase from twelve hours to fourteen days after operation. The activity of mitochondrial aspartate aminotransferase in the cholestatic liver strikingly decreased between the third and the forty-second days of the operation.