Effect of Hypotensive Epidural Anesthesia and Tranexamic Acid
on Perioperative Blood Loss |
저혈압 유도성 경막외 마취와 Tranexamic Acid 투여가 주술기 출혈량에 미치는 효과 |
이용철; 박지훈 |
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Abstract |
We conducted present study to evaluate and compare the effect of hypotensive epidural
anesthesia (HEA); tranexamic acid (TA) and combined HEA with TA on reducing perioperative
blood loss and transfusion requirements in total hip replacement (THR) under general anesthesia.
We reviewed medical records of primary unilateral cementless THR under general anesthesia.
Twenty four patients who were underwent HEA were assigned as group 1; twenty three patients
who received TA were assigned as group 2; twenty two patients who were underwent HEA and
received TA were assigned as group 3. Intraoperative blood loss in group 1; 2; and 3 was 253.5
± 148.9; 422.4 ± 217.5; and 235.9 ± 119.4 ml; respectively. Group 2 displayed a significantly
larger amount of intraoperative blood loss compared to group 1 and 3. Postoperative blood loss in
group 1; 2; and 3 was 1074.5 ± 325.5; 477.0 ± 352.7; and 438.7 ± 211.3 ml; respectively.
Postoperative blood loss was significantly reduced in group 2 and 3 compared with group 1. Total
blood loss in group 1; 2; and 3 was 1326.4 ± 414.2; 913.9 ± 427.5; 675.2 ± 251.4 mL; respectively.
Total blood loss was significantly reduced in group 2 and 3 compared with group 1. Combination of HEA
and TA administration reduced both intraoperative and postoperative blood loss. |
Key Words:
Blood loss, Hypotensive epidural anesthesia, Total hip replacement, Tranexamic acid |